On the Beach were crowned winners in the turnover of £100m or more category.
They beat Manchester Airports Group, IT security company NCC Group, and coach and holiday specialist Shearings Group at the event at the Midland Hotel in Manchester.
In the £5m-£10m turnover category, the winner was Cheadle technology firm Avecto, which won out over creative company Rhino Design, from Hyde, and Hazel Grove coatings specialist Resin Surfaces.
M.E.N. Media associate editor Adam Jupp said: “What is great about these awards is they recognise the achievements of businesses of all shapes and sizes and at all stages of their growth journeys.
“The region’s best businesses are of huge importance to us all, in terms of creating jobs, economic output and creating a general sense of optimism and well-being.
“That is why it is great to celebrate their success. Thanks, as always, go to our sponsors and all those who entered the awards and played a part in organising another fantastic event.”
There is a full list of winners on the M.E.N website.